Mitochondrial uncoupling proteins and energy metabolism
نویسندگان
چکیده
منابع مشابه
Mitochondrial uncoupling proteins and energy metabolism
Understanding the metabolic factors that contribute to energy metabolism (EM) is critical for the development of new treatments for obesity and related diseases. Mitochondrial oxidative phosphorylation is not perfectly coupled to ATP synthesis, and the process of proton-leak plays a crucial role. Proton-leak accounts for a significant part of the resting metabolic rate (RMR) and therefore enhan...
متن کاملUncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.
Mitochondria use energy derived from fuel combustion to create a proton electrochemical gradient across the mitochondrial inner membrane. This intermediate form of energy is then used by ATP synthase to synthesize ATP. Uncoupling protein-1 (UCP1) is a brown fat-specific mitochondrial inner membrane protein with proton transport activity. UCP1 catalyzes a highly regulated proton leak, converting...
متن کاملMitochondrial uncoupling proteins
The aim of this review is to provide an overview of current knowledge on the three mammalian uncoupling proteins, UCP-1, UCP-2, and UCP-3. Heart Metab. 2010;48:32–34.
متن کاملMitochondrial uncoupling and lipid metabolism in adipocytes.
Metabolism of white adipose tissue is involved in the control of body fat content. In vitro experiments indicated a dependence of lipogenesis on mitochondrial ATP production, as well as a reciprocal link between hormonal effects on metabolism and energetics of adipocytes. Therefore, mitochondrial uncoupling in adipocytes that results in stimulation of energy dissipation and depression of ATP sy...
متن کاملMitochondrial proton leak and the uncoupling proteins.
An energetically significant leak of protons occurs across the mitochondrial inner membranes of eukaryotic cells. This seemingly wasteful proton leak accounts for at least 20% of the standard metabolic rate of a rat. There is evidence that it makes a similar contribution to standard metabolic rate in a lizard. Proton conductance of the mitochondrial inner membrane can be considered as having tw...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2015
ISSN: 1664-042X
DOI: 10.3389/fphys.2015.00036